Causes of HFI

[lazerlee]

Currently, a Medical diagnosis of HFI does not distinguish between Aldolase B and Fructose Bi-Phosphatase enzyme dis-function. The list below are methods by which Fructose Metabolism (HFI) the medical diagnosis may occur.
- There is no industry accepted published medical diagnostic criteria for a HFI diagnosis... A Doctor's opinion is an opinion, hopefully confirmation testing will direct the doctor to an appropriate cause/treatment, if available.-

1... Virus infecting the replication Transcription Factor (HMF3 -ALDOB or HMF4 - FBPase) that prevents the creation of the corresponding Enzyme.

2... Virus infecting the Autophagy process that cleans broken enzymes from a cell.

3... Hydroxynaphthaldehyde Phosphate (Schiff base, derivatives of) cause defective Enzymes of Fructose 1,6 Biphosphatase, may be released from some microorganisms.

4... Carboxypeptidase A. (CBP derivatives of) are released from some microorganisms and can cause the creation of non functioning Aldalose B.

5... A genetic mutation in the Aldalose B Gene, very few have been identified to cause medical HFI (2-6% of alternative AldoB Genes... Commercial Genetic testing is inconclusive.)

6... A genetic defect in the FBPase Gene, (several known defects exist.)

7... A virus may be attached to the outside of a cell (via its own adhesion protein) or in contact with a cell and may induce "neurological issues" that prevent proper Enzyme function. (a characteristic of some Enteroviruses)

8... Genetic defects and other issues with breakdown, transformation and absorption of Sucrose and Sorbitol in the small intestine are often times mistakenly attributed to HFI (primarily Liver Enzyme metabolism).

[lazerlee]

In general, the incidence of a "Strictly Genetic HFI" from an AldoB cause is from 1:250,000 to 1:1,500,000.(derived from 1:15,000 alternative Gene incidence and the 2-6% promoter flaw). There were about 4 million births in the US in the year 2020--- 3 to 16 children born with "Genetic HFI" from AldoB born in that year

(It has not been determined how the Enzyme creation process from genetic instruction interact with organic molecules and alternative compound structures from micro organisms. Other then a few known toxins.)


Looking for studies that distinguish between the AldoB alternative Genes and the defective promotor region flaws.

[ukbill]

Tests done on large sample of heal prick blood tests done in the UK come up with a 1:15,000 incidence for known versions of HFI.

We know there are more.

So you are quite a long way off the mark there.

As I have said befor only number 5 results in HFI all the other do not. They might cause various conditions similar to, but not the same as HFI

[lazerlee]

Having an alternative Protein Coding section of the Aldolase B Gene usually does not result in Medically Diagnosable HFI... There does appear to be a relationship to a defect in the Promoter Region of a small percentage of those Alternative Genes that corresponds to a Medical Diagnosis of HFI.

How do you "justify" more incidence of Medically Diagnosed HFI without a medical diagnosis?

[lazerlee]

Having the option (without hospitalization and death) to significantly reduce the possibility of Cardiovascular Disease,Type II Diabetes and Cancer... My Vegan/Vegetarian Lifestyle is statistically Healthier, provided that I don't become vitamin and/or mineral deprived. (High Quality supplements are available and I take them.)

pubmed.ncbi.nlm.nih.gov/26780279/

I appreciate that HFI limits dietary options, but the necessity of one person may not be the best option for others.

[lazerlee]

While looking into fighting viruses with food, i did run into an article that explained how the amino acid profile of a persons diet may effect viral replication.


A higher ratio of the amino acid Arginine to Lysine, sometimes associated with plant-based protein consumption may stimulate increased viral reproduction. If this is the case, an adjustment to a red meat based Antiviral diet might improve the immune system response.

Your personal advise. As well meaning as you intend it, is no substitute for a practicing physician, hospital or medical clinic... It is no wonder why Americans appear rude and obnoxious to those in other countries, we (generally all people) mirror according to our personal and cultural norms what is being or has been experienced... "The pot calling the kettle black."

Most paternal/masculine cultures still primarily appreciate MYOB as the Ideal... The alternative devolves into uniformity, mediocrity and eventually social rebellion as the social stresses of the people build...

[ukbill]

Mar 16, 2022 22:59:16 GMT -5 lazerlee said:

Having the option (without hospitalization and death) to significantly reduce the possibility of Cardiovascular Disease,Type II Diabetes and Cancer... My Vegan/Vegetarian Lifestyle is statistically Healthier, provided that I don't become vitamin and/or mineral deprived. (High Quality supplements are available and I take them.)

pubmed.ncbi.nlm.nih.gov/26780279/

I appreciate that HFI limits dietary options, but the necessity of one person may not be the best option for others.

Unfortunately it (Vegan / Vegetarian Lifestyle) also exposes anyone with HFI to far too much Fructose and digestible fibre.

These things (Fructosemia and other conditions of similar nature) do not have the same critical levels as in HFI.

Someone with Fructosemia for example, will not have the digestive issues those of us with HFI have.

For anyone with HFI (as opposed to other issues with fructose metabolism) even a Vegetarian diet would cause serious issues with health and liver function, Veganism would be suicide as I have stated many times.

This has been also confirmed to me by the specialists and the Doctors I deal with.

I had discovered that Fructosemia is not the same as HFI but until I looked into the specifics, I did not understand the differences between the two conditions.

Thanks you for challenging me and getting me to think afresh and deeper so to learn more about the condition.

It helps me give safe advise to HFI'ers and others.