HFI myths

[lazerlee]

The biggest myths I Have run across about HFI...

The Aldolase B Gene being Identified as the HFI Gene,

Most Genetic causes of HFI are from the FBPase Gene where many known defects are recognized and can be screened for.
The screening for the Aldolase B Gene Identifies "defects" that requires an additional Glucose molecule to process Fructose... Has no bearing on a person being medically Diagnosed as having HFI.

(A Genetic Identification that uses the same label as a Medical Diagnose. That is how I found the message board/support group)

[lazerlee]

Myrh: HFI must be Genetic


With hundreds of viruses that may infect humans, and an untold number of bacteria, fungi, protozoa and other single cell organisms that create toxins that cause liver damage a Genetic cause is not guaranteed.


This myth about a genetic componant was originally used to explain how Fructose Malabsorption was different from HFI... (FM has no known genetic component/contribution. Sucrose and Sorbitol Intolerance disorders have their own genes involved for their absorption/metabolization.)

[lazerlee]

Myth: A diagnosis of HFI actually means having/being reactive to Fructose.

HFI is a "blanket" diagnosis for Metabolic issues that use the Aldolase B Enzyme. Toxins that cause Liver damage can be released by fermentation from bacteria in the intestines of a specific type of molecule (Sucrose, Fructose, Sucralose, etc... Including Sorbitol and undigestable Fructans/Fibre.) It is not known which bacteria or fermentation of which molecules create the toxins that damage the Liver.

Because of the life threatening potential, and natural changes in the biome of the intestines throughout life, differentiation is not performed, A Confirmation test/biopsy is important as it measures the ability to metabolize Fructose at the time of the test, the ability of the liver to heal and the amount of toxic exposure varies from person to person.

[lazerlee]

Myth:

The current designation in the DNA for AldoB and FBPase are the same as when designated in the 80's.

The designation of 9q22.3 is for FBPase, originally it was part of the AldoB designated range of 9q13-9q32.

This range has been further divided and other Genes have been designated in the original range.

pubmed.ncbi.nlm.nih.gov/3000275/

[ukbill]

LOL no not myths simple proven facts.