Cause of HFI (AldoB and FBPase)

[lazerlee]

Currently, a Medical diagnosis of HFI does not distinguish between Aldolase B and Fructose Bi-Phosphatase enzyme dis-function. The list below are methods by which Fructose Metabolism (HFI - medical diagnosis) may occur.

1... Virus like Hepatitis B infecting the replication Transcription Factor (HNF3 -ALDOB or HNF4 - FBPase) that prevents the creation of the corresponding Enzyme.

2... Virus like Coxsackie A16 infecting the Autophagy process that cleans broken enzymes from a cell in preparation for a new one.

3... When a virus overwhelms a body to a state called Chronic Fatigue where the viruses coat cell surfaces preventing proper flow of nutrients.

4... A bacterial or fungal infection that releses an organic toxin [Schiff base or derivative] that cause damage to the Fructose 1,6 Biphosphatase.

5... A unique or very rare Aldalose B Gene in which the placement location info part of the Gene is bad. A very specific HFI genetic identification.

6.. A protozoa [Trypanosoma brucei] emits a chemical [hydroxynaphthaldehyde phosphate] that damages the Fructose 1,6 Biphosphatase  The protozoa is the source/cause of African sleeping sickness Disease.

7... hydroxynaphthaldehyde phosphate and many derivates (used to detect radiation and used in photography) are known to cause damage to the Fructose 1,6 Biphosphatase Enzyme

8... A genetic defect in the FBPase Gene, (several known defects exist.)

[ukbill]

Yes it does you are wrong on your basic assumption.

[lazerlee]

Revised...


1... Virus infecting the replication Transcription Factor (HMF3 -ALDOB or HMF4 - FBPase) that prevents the creation of the corresponding Enzyme.

2... Virus infecting the Autophagy process that cleans broken enzymes from a cell.

3... Hydroxynaphthaldehyde Phosphate (Schiff base, derivatives of) cause defective Enzymes of Fructose 1,6 Biphosphatase, may be released from some microorganisms.

4... Carboxypeptidase A. (CBP derivatives of) are released from some microorganisms and can cause the creation of non functioning Aldalose B.

5... A genetic mutation in the Aldalose B Gene, very few have been identified to cause medical HFI.

6... A genetic defect in the FBPase Gene, (several known defects exist.)

[ukbill]

Only number 5 has in any way a relationship to HFI.


1.2.3 /. Viruses are usually transitional and are cleared out of a persons system in due time, so temporary Fructose intolerance would be the likely result should someone get infected with a specific virus. The other conditions mentioned would not cause FI.

4/. No microorganism is going to cause FI or anything similar because the existing Aldaloise B in the person concerned would be perfectly functioning and do the Fructose phosphate conversion as per normal.
6/. FBPhase is a different condition altogether, so you should address those questions to a forum for that condition.

[lazerlee]

Using the revised list


It is interesting how potential causes are ruled out... But without a published medical Diagnosis Criteria officially accepted by the industry, A Doctor has the potential (while following protocol) to identify a viral infection or issues with FBPase as being attibuted to Aldolase B, I would hope that the confirmation tests would redirect the doctor(s) to the appropriate cause.

.. Not all viruses clear the body/organs when the immune system and the body adapts. Examples being Hepetitis B, Epstien-bar and Enteroviri [Coxsackie A, Coxsackie B, Echoviri, etc...]
..With Enteroviri as long as the immune system can match or beat the mutation rate of the viri, then the viri stays contained (i.e.attached to the outside of uninfected cells.) It is a defective strain of Enterovirus that gets completely cleared from the body, while the introduction of a new/diferent virus into the body provides a new virus DNA to recombine with..

(I am still actively fighting back against my Enterovirus infection.)

[lazerlee]

I regards to having working Aldalose B while being consistently exposed to a toxin that causes an Enzyme defect. It is not going to be clear.

The cells of the liver are normally replaced every 300 days, The quantity and distribution of the toxins across the liver cells (including the upper lobe) is also unknown.

[lazerlee]

I am curious if any of the organic compounds made in the manufacture of Enzymes are even recognized by the liver as needing to be removed from the blood...

The alternative is that the kidneys actively retrieve metabolic molecules, amino acids, water, etc... From the filtration done by the cortex of the kidneys.

[lazerlee]

I finally got down to the root cause of my issues with Fructose...

As a toddler me and my Infant brother were hospitalized because of life threatening Liver problems. (Medical diagnosis... Indeterminate Hepetitis A) Although we both recovered, I have always had issues with hypoglycemia and high Fructose levels at night.


I do not know which of the Coxsackie B Viri we acquired. Howwever even after imunity from a viral infection is acquired many varieties of Enterovirus have "neurological" effects on organs/tissues when attached to the outside of a cell.


With this new understanding of how some Viri can have an effect without an active cellular infection, an additional method of AldoB/FBPase disfunction may occur.

7... A virus may be attached to the outside of a cell (via its own adhesion protein.) The Liver, Small Intestine or kidneys may be experiencing "neurological issues" originating from the virus on the outside of the cell and therby preventing proper Enzyme function.

[ukbill]

I am sure you have been asked many times before but cannot find an answer from you..

Have you been genetically tested for HFI?

Did they do a full Genome scan or just look for the more common occurances?

Liver damage such as can be caused by Hepatitis, can cause Fructosemia, however this is not exactly the same as HFI depending as it does on the amount of damage done, and the amount of remaining working liver that keeps producing working Aldalose B. As will the kidneys of course, and you will not have the intestinal issues we also have.

Also if your Fructosemia has been caused by Hepatitis as you surmise, your liver will not be extensively damaged by further Fructose in your diet.

This is probably the reason you are still alive on a VEGAN diet, which besides being dangerous for anyone to be on, is of course completely lethal for anyone with HFI

I wish you health and happiness and hope you can stabilise your diet to reduce the issues you are having, hint.. switching to a vegetarian diet or a proper safe omnivore diet will help you a lot.