A possible reason why we "react" differently to sugars

[ukbill]

I have just had a brainwave..
We frequently have different reactions and responses to HFI.
The same gene errors causing a lot of variation in sensitivity and levels of reaction that we have all been trying to understand.
I think I have an answer.

DNA is the instruction book effectively am I right?
RNA is the book reader?
Hence Evolution.

RNA changes through our lives due to environmental impact.
It changes as a result of (for example) virus attack to help the body detect the same virus again.
It is why identical twins at birth usually look different, if they separate and live different lives the changes are more pronounced.
Cloning the DNA of Dolly the Sheep produced a sheep that is genetically it is the same yet looks different and has different issues in it's life.
This is due to the way the different RNA has read the DNA instruction book, They only inserted the DNA from the "parent" sheep not the RNA.

I may be way off target, however I put this up for everyone's thoughts and comments.

Keep smiling.🙂

[ukbill]

Yes It could be wrong I put this to Prof Cox the expert on the clinical side of HFI
He said in reply:-
There is variation but it is going to be environmental developmental and psychosocial, behavioural, and just a little genetic control of metabolism, taste perception and say gastro-intestinal motility. The evidence is very little at the genetics specifically of the mutations.

Until we quantify the dose and symptom relationship we are stuck!

All best,

Tim
then following
even so-called identical twins! But although mothers treat them differently in a pedigree the ALDOB mutations themselves are very likely to be identical. There are exceptions (see the attached), but the genetic modifiers are a possibility.

Attachments:

221021 prof cox.pdf (726.39 KB)