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Post by Jsimpson on Dec 3, 2016 19:25:02 GMT -5
Hello! My mother has HFI and I did genetic testing with 23andme last summer and found out that I am a carrier (as is my older daughter). When I was pregnant earlier this year and had th gestational diabetes test, I opted for the food version so had the level drawn before and 2 hours after a special shake. My 2 hour results were lower than my fasting so I was diagnosed with reactive hypoglycemia. I assume this is as from the HFI gene and stress from pregnancy. I'm not having that issue now that the baby is born but I'm wondering if I need to take any special precautions or steps as a carrier. I remember getting hypoglycemic anytime I ate plain chocolate as a teenager (stuff with peanuts was ok- maybe that slowed absorption?) so I wonder if this is something that has effected me all my life and I just didn't realize. I also found out in the genetic testing I'm homozygous a1298c mthfr and am gluten free, dairy sensitive. I'm 33 and feel like things started catching up with me a couple years ago...
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Post by rysmom14 on Dec 4, 2016 21:15:45 GMT -5
Hello Jsimpson,
My son Has HFI so therefore my husband and I are carriers. I think that since there is so little research on HFI in general, that there is even less information and research about the carriers. This is our first experience with HFI and there is no one else in our family that has it. one of each of out parents would have to be carriers, but we never looked into that.
Neither of us has ever had problems that could be tied to HFI, or even a mild aversion to sweets. When I was pregnant with my son, I failed my glucose test because It was too high and was diagnosed with gestational diabetes. The physicians are attributing this to the fact that I was pregnant with fraternal twins, so there were 2 different placentas so there is an already increased chance for gestational diabetes. That being said, it was mild and was able to be controlled by diet. my second pregnancy I did not have diabetes. so out of my 3 children, My son has HFI, his twin sister is a carrier and their baby sister has nothing.
From the little bit that his genetics Dr.told us when my son was diagnosed was that carriers are usually just that, a carrier, and they usually exhibit no symptoms. especially in the case of HFI where you need 2 recessive genes to have this condition.
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Post by colormist on Dec 5, 2016 9:32:15 GMT -5
My mom (a carrier of the HFI gene) has hypoglycemia. She's always needing something to bring her blood-sugar levels back up to normal. I usually share my emergency Smarties with her when we're out and about and her blood sugar goes low.
My dad does not talk about his medical issues at all, so I'm not sure if he ever gets hypoglycemic.
I really don't know if this is related to being an HFI-carrier, though. My geneticist seemed curious about it when I mentioned it to him, but we didn't do any family testing to find out if HFI might have been the cause of her hypoglycemia. I am doubtful, though, since you need the two genes to have the aldolase b deficiency.
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Post by jsimpson on Dec 6, 2016 8:45:29 GMT -5
My mother has 5 siblings and one other has been diagnosed HFI and I believe 2 others are sensitive to sugar with a tendency toward hypoglycemia. I was just curious if having the carrier gene effected the bodies ability to make the enzyme- reduced the ability really.
It sounds like carriers at least have a tendency toward hypoglycemia.
Has anyone heard of the sugarbug vein some babies have? I've just been reading about it and it is a blue vein on the bridge of the nose and babies with it tend to be more cranky and crave routine but also sensitive to sugar- even just fruit- as they begin solids. Both of my girls had these (not very noticeable because their skin isn't very pale) and my older daughter is a carrier of HFI like me. I just thought it would be fascinating if there's this physical sign but no one realized what it meant!
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Post by ukbill on Dec 6, 2016 18:20:49 GMT -5
I know my Grandfather on my mothers side was slow to convert body fat back into blood sugar (as I am too) and could go Hypo if he exercised without having eaten enough.
He always had to sit down with a cup of tea and bread and butter and a piece of cheese if he was hypo.
My Mother is fine however and no other signs of HFI except she does not have a sweet tooth and prefers savory none sweet foods to sweet foods any day.
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Post by rysmom14 on Dec 6, 2016 23:00:16 GMT -5
I heard about the sugar vein! so of my 3 kids, the HFI carrier and the baby with nothing had this sugar vein. They both love fruit and are much more easy going then my HFI child. He needs routine. He cant skip naps of snack or he has a terrible night with night terrors. I am interested to see if as they get older if they are more sensitive to sweets.
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