Post by adrian on Oct 9, 2012 22:15:52 GMT -5
The good folks at BU are on the case, this is some recent news that could lead to important treatments involving small molecule drugs based on the effect of glycine on HFI type aldolase of alanine-proline switch type (most common form of hfi) : gradworks.umi.com/34/83/3483531.html
Basically, the the two proteins alanine and proline are in the wrong positions, the resulting aldolase b that HFIers end up with are unstable and break down quickly. This leads to a 200 fold reduction in aldolase B for people with HFI...it has been found that Glycine protects this form of aldolase that people with HFI make, giving it stability and the ability to proliferate and to do its job in metabolizing fructose.
The potential for developing small molecule drugs that do what glycine does is promising as a complete treatment.
Imagine, having your birthday icecream cake and EATING it too, without fear of illness!!! (anyway, I know that thought is gross to most of you)
Basically, the the two proteins alanine and proline are in the wrong positions, the resulting aldolase b that HFIers end up with are unstable and break down quickly. This leads to a 200 fold reduction in aldolase B for people with HFI...it has been found that Glycine protects this form of aldolase that people with HFI make, giving it stability and the ability to proliferate and to do its job in metabolizing fructose.
The potential for developing small molecule drugs that do what glycine does is promising as a complete treatment.
Imagine, having your birthday icecream cake and EATING it too, without fear of illness!!! (anyway, I know that thought is gross to most of you)
