Medical Journal Article

[susan]

Here is an article I found interesting. It may be listed somewhere on this HFI site. If so, my apologies.

It is still not as resent as I would like, only 1998. Yet it seems to be a medical journal versus some recycled web information.

jmg.bmj.com/content/35/5/353.full.pdf

It also talks about populations who may carry the mutation. Fascinating for me. Then I start thinking about the origin of HFI and the idea of 'the far north' and central Europe. My mind ponders. There have been major and minor "ice ages". Conditions the same as the 'far north' were sometimes in central Europe. Then I consider human migration during ancient times. Fascinating. Susan

[esmee]

Thank you Susan! I am printing it out right now.

[susan]

Read past the introduction of the subject to the main part of the article. The introductions always have to state past research.

www.ncbi.nlm.nih.gov/pmc/articles/PMC2684612/

Susan

[susan]

2009 Medical Journal Article.
Be sure to read past the introduction of the article to get to the main part. They always have to cover past literature in the introductions.

www.ncbi.nlm.nih.gov/pmc/articles/PMC2684612/

Susan

[susan]

2002 Molecular analysis of the aldolase B gene in patients with hereditary fructose intolerance from Spain

jmg.highwire.org/content/39/9/e56.full

Susan

[ukbill]

Excellent research! well found both of you!

The way things are going shortly this site will be a major source of information for anyone wanting to research Sugar metabolism and Genetic controls of the same.

I do not understand much of it but it will help any medical professional who is looking to advise and help the parents of an HFI child.

If anyone can translate the information into normal understandable none medical speak then I would love to understand the results better.

[adrian]

Here is a link to 71 in depth articles done by Dr. Tolan www.ncbi.nlm.nih.gov/pubmed?term=%22Tolan%20DR%22%5BAuthor%5D

Many of them are fascinating reads

some of the more interesting ones include: how people with HFI actually metabolize fructose in the brain.

also how HFI can keep blood sugar normal in the absence of fructose during a fast despite not having a key Gluconeogenesis (turning protein to glucose) enzyme aldolase b. this contradicts all metabolism textbooks. We do this more efficiently then normal people and we do it outside of the liver, which is a big surprise.