Recent Professional Journals on HFI

[tummyache]

Recent Journal Articles or Abstracts of Articles on HFI that may be of interest:

[1] Management of hereditary fructose intolerance in pregnancy, Abstract, Journal of Paediatictrics, Volume 53, Issue S2, April 2017, Page 11, Abstracts of the 21st Annual Congress of the Perinatal Society of Australia and New Zealand [http://onlinelibrary.wiley.com/doi/10.1111/jpc.13494_26/full]

[2] Inborn Errors of Fructose Metabolism. What Can We Learn from Them?, Full Article, Christel Tran, Nutrients 2017, 9(4), 356; doi:10.3390/nu904035, Center for Molecular Diseases, Division of Genetic Medicine, Lausanne University Hospital (CHUV), Beaumont-02/248, Lausanne CH-1011, Switzerland, [http://www.mdpi.com/2072-6643/9/4/356/htm]

[colormist]

Did I read that pregnancy article right? The baby had a hypoglycemic incident when he was 4 hours old??

I have been curious about gestational diabetes and how HFI might complicate that condition (and the test to check for that condition).

In the second article: "Recently it has been demonstrated that fructose is also produced endogenously from glucose by the human brain via the polyol pathway [3]." Well, nuts. Seems like it's impossible for HFIers to get away from fructose. I really hope that treatment medication comes along soon.

This bit in the second article is also interesting (in reference to HFI carriers):
"Based on this, a (HFI) carrier frequency is predicted between 1:55 and 1:120. Although heterozygous carriers have no reported metabolic defects, they may have enhanced uric acid responses to IV and oral fructose load (50 g) according to some reports. Assuming that estimated oral fructose consumption might reach 50 g/day in the United States, heterozygous carriers may be predisposed to gout. Speculation about fructose intake and gout was raised about 50 years ago, and in some patients with gout hyperuricemia, the frequency of gouty attack was reduced by a fructose restricted diet. It seems possible that those who benefited were heterozygous for HFI. Recently a meta-analysis of prospective cohorts studies investigating total fructose consumption and its association with incident hyperuricemia and gout concluded with a significant overall association. However the strength of evidence for the association between fructose consumption and risk of gout was low, meaning that further prospective studies are needed to conclude on which extent fructose may mediate the risk of hyperuricemia and gout."

My mom does not eat a lot of fructose, but my father is well over the 50g/day threshold. This might be something to bring up with your parents (or pay attention to yourself, if you're the parent of an HFIer).

[rysmom14]

when my son was born, they checked blood sugars and his was normal low and I kept trying to get him to nurse, but he wouldn't latch ( my little 4 lb 9 oz ball of fire) and they had to check it again in the next time frame and it was "dangerous low" and they went into protocol mode, and they had to feed him formula, and then put him on a mandatory sugar check every so many hours.

I never thought much about it then because it was overwhelming being a first time mom, but that may have been something worth paying attention too. When he went into the hospital at 2 months old for hernia surgery he had problems keping his sugars up in normal range too, but I thought it was because he was so small. he may have only been 8 lbs by then and had fasted so long for the procedure. but if he was eating formula with sugar, if makes sense he would go hypo, or actually maybe even be hypo a lot of the time.

[ukbill]

I am convinced that Fructose eaten by the mother can pass the barrier in the Placenta and get itno baby. It might explain why there are so few of us.

Also evidence seems to be that fructose eaten my a nursing mother can also get into the Mothers milk.